According to the National Institutes of Health handout on rheumatoid arthritis, "Rheumatoid arthritis is an inflammatory disease that causes pain, swelling, stiffness, and loss of function in the joints. It has several special features that make it different from other kinds of arthritis. For example, rheumatoid arthritis generally occurs in a symmetrical pattern, meaning that if one knee or hand is involved, the other one also is. The disease often affects the wrist joints and the finger joints closest to the hand. It can also affect other parts of the body besides the joints. In addition, people with rheumatoid arthritis may have fatigue, occasional fevers, and a general sense of not feeling well. Rheumatoid arthritis affects people differently."

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Rheumatoid arthritis is a chronic disease. Rheumatoid arthritis may not go away.  Other people have mild or moderate forms of the disease, with periods of worsening symptoms, called flares, and periods in which they feel better, called remissions. Still others have a severe form of the disease that is active most of the time, lasts for many years or a lifetime, and leads to serious joint damage and disability. Frequent flares in disease activity can occur. Rheumatoid arthritis is a systemic disease, which means it can affect other organs in the body.